Josephine
NURSE DIRECTOR EMERITA
It's most unlikely that anyone will get a tolerance to NSAIDs insofar as pain relief is concerned but evidence is that gastric problems/bleeds can occur quite suddenly whether you take them for years or just a day or two. And gastric bleeds in this situation can be quite catastrophic requiring emergency surgery and a transfusion of blood in significant quantities. Much better not to run the risk.My main concern is developing a tolerance to them where they won't help my pain. I have been using ibu, either the 800mg rx ones, or the pm otc ones for years and don't have any gastric issues.
My experience is, when asked specifically, that Americans say but have tended to take just one regular Tylenol which is 325mg which is why they don't feel any benefit. Because the correct and effective dose is 1,000mg up to 4 times per 24hrs. And yes, Tylenol certainly can have a deleterious effect upon the liver but the key is in the "too much". Provided you don't exceed the recommended amount per 24hrs. which is 4,000mg it is perfectly safe provided also that your liver is healthy!I've never found Tylenol to have any effect on my pain. Any thought? I've (also) heard that too much tylenol can cause liver problems
United Kingdom