I drove at 2 weeks with my Left knee and at about 3 weeks with my Right. As Celle said, you need to be off the narcotics because it's considered DUI to drive while taking them, and you need to be able to react quickly. My surgeon left it up to me and said to do it when I felt comfortable. I had to be at 90 deg flexion to leave the hospital in order to get in and out of the car, so that was already established, and I think a little more than that is needed in order to comfortably get in and out to drive. I have a large SUV so getting in and out was easy, and I parked where I could get the doors to open wide so that helped. I also practiced around the neighborhood a couple of times before venturing out on the roads. I'm not sure if you thought of this ahead of time, but I downloaded a temporary handicapped parking form off the KY transportation website and had my primary doc sign it so that I could park close for the 1st 3 months after surgery. That helped a lot.