I quit pain meds after 3 days. I did take regular tylenol for two weeks after that. For me the more I moved the better my knee felt, so I started moving right away. Lots of moving, gym every day and lots of resting. I went back to work I think 6 weeks after my first knee was done last year. This knee I waited 10 weeks and started with a light schedule (I have a very active job where I am on my feet moving the entire time).