SAM-e affects each person differently, because some people naturally produce it, and others are deficient. You will know how deficient you are in it by how great you feel when you take it. But it builds up in your system over time, so you might not feel the fulll effect until after 3 or 4 weeks.
I also take Rhodiola Rosea, which is only grown in Siberia, and is a natural mood lifter. They take it in Siberia to keep from getting depressed in the long winters there. Dr. Mehmet Oz says he puts Rhodiola in his martini.
Together, the two supplements keep me feeling great. Nothing really bothers me anymore when i take them. But the best part is that SAM-e maintains joint cartilage, which we all could use here!
Hop