I have had hip and knee replacement surgery with basically no problems until last year. I was curious to see if anyone has heard of or experienced anything close to what I have encountered in the last 15 months. In May of 2017 I had a revision on my left knee that was totally replaced in 2006. A week before my revision I started taking Harvoni to cure my Hepatitis C that I acquired in the early 70's from several blood transfusions. Everything was fine for about 3 months and then I started developing swelling and pain. In Oct. 2017 the TKR was removed and a spacer was put in and also a PICC line where I got 2 bags of antibiotics to fight infection. The strange thing was that no one could identify any infection with all the blood work that was done. On Dec 26, 2017 the spacer was removed and a TKR installed. For 3 months everything was great and then it all started again. For a 2nd opinion my doctor sent me to Tulane Medical Center and once again, no one can find any infection. A 3D bone scan of the knee came back abnormal and am waiting for a full body scan that the doctor at Tulane Medical has ordered. I was informed that this latest total knee was going to have to come out. My orthopedic surgeon is questioning whether or not the Harvoni taken for my Hep C could have anything to do with my body rejecting my knee replacement surgery. My doctor enquired about the Harvoni prior to my surgery last year and was assured it didn't suppress the immune system at all. This is the 1st letter I have written in regards to my situation but felt I have to start somewhere. Any suggestions?