I’m so glad to find this out, because I use Benedryl often for my allergic reactions, bee stings, etc. I don’t think I haven’t had 7 hours straight for a while. Just can’t seem to get comfortable at night. Glad that you got things figured out & are sleeping the night through. It makes all the difference how you feel the next day.It was a surprise to discover that the active ingredient in my favorite antihistamine, Benedryl, can cause RLS. Now I'm checking everything for side effects and interactions. Where I live is the grass seed capital of the world, so allergies are a part of life. The Benedryl is in my medical records and I don't have issues with it at other times, so maybe a chemical reaction with something else they had me using.