I had a TKR on my right knee on Leap Day (how appropriate) of 2008. I am 59 and in pretty good health, aside from a few heart rhythm issues now and then. I thought everything was going really well, until this weekend. My doctor prescribed hydrochodone for my pain when I came home from the hospital. I started with 12 pills a day and had worked down to 8 this past Friday and 6 on Saturday. But starting Saturday, I became so nauseated and sick to my stomach that I felt I needed to do something different. I took my last pain pill Saturday night at 11:00 p.m. Sunday morning, I was still miserable....not so much the pain, but more the nausea and extreme tiredness. The on-call doctor agreed with me that the problem was likely the pain med. He told me it would be okay to stop cold turkey if I wanted to or I could try a half a pill with something to eat. I opted to stop completely. I was okay for most of the day pain-wise, but here it is the middle of the night and I cannot sleep. I'm tired. The knee doesn't hurt too terribly. It's just that when I lie down, I can't stop moving my legs around and I never get comfortable. I came in to the computer to read some of the posts from this wonderful board and decided to join. It sounds like my experience might be something that just happens. I would welcome any advice or help anyone could offer. I plan to call my doctor tomorrow (Monday) and see if there is a different medication for pain he could give me that does not have the same ingredient as the hydrochodone....I have had problems with Tylenol before and think this may be why my stomach is so upset now.