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Impact of Low-dose Prednisolone on Bone Synthesis

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nickji

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Hi Everyone,

This link is mainly for those with RA, though it might possibly be useful for any THR if there's an inflammatory response, Josephine will doubtless know. I was interested because Prednisolone is amazingly effective for gout pain, but of course has a dreadful reputation, which this article seems to somewhat mitigate. The text is a bit obscure, but the conclusions seem clear enough. Here's the link:

https://www.medscape.com/viewarticle/587608?src=mp&spon=17&uac=126271MX

Enjoy it all,

Nick
 
Yep, that's pretty much the regular experience with steriods of all kinds.
 
Yep, that's pretty much the regular experience with steriods of all kinds.

Hi Josephine,
I'm confused - I'd always thought that steroids were just bad for bones, and here's an article saying that prednisolone can actually preserve or improve bone mineral density of the femur in low doses. Has that always been the general consensus?
Nick
 
Depends upon the patient - some do, some don't. The biggest problem I've seen is that the soft tissue - especially the skin - become very friable after a long time on steriods. But even that varies.
 
Why is it that the only drug that's good for my gout pain is so variable that I daren't use it :-( But thanks for clarifying its unclarifiable nature - helps to keep my sticky fingers off it. :-)
Nick
 
Nick
I am having the debate over using a low dose of steroids myself. They help tremendously with my joint/back pain, but the long term side effects (or not so long term) are bad.
I feel so much better when I take them and have just been given a prescription by a rheumatalogist for my next flare, but I feel I should burn the prescription.
Last month my spine doc gave me a medrol dose pak ( 6 day dose) I felt so great in 12 hours, I could hardly believe it.

So I feel your pain

As of today my doc really wants the cause of the inflammation to be found .
judy
 
Hi Judy,

I've decided that if I have a flare-up then I'm willing to take steriods for a maximum of two or three days in any given monthly period. The side effect that concerns me most is the increased risk of infection, but I can't imagine that a few days is going to harm me. Incidentally, some joint surgeons warn never to have a corticosteroid injection near a joint replacement site because of this infection risk.

Good luck finding the cause.

Enjoy it all,

Nick
 
Oh it won't harm for just a few days. The damage is done by long term use - several months.
 
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