I'm not sure why you would have this different reaction. I'm betting it has something to do with the way the medication is designed - to release the active ingredient (acetaminophen) into your system. Perhaps with "rapid release" the pills release a heavy-duty portion up front followed by the rest of the dose over 4-6 hours. I know with the "extended relief" Tylenol, relief also doesn't work after joint replacement surgery because the dose is released gradually over 6 hours. You never get enough of the active ingredient to do the job this way.
You are much better off taking just regular old Extra Strength Tylenol (2x 500mg tablets) for a regular dose, not to exceed 4000mg in any 24 hour period. You must also count the acetaminophen in any other meds you take (pain medications or cold and sinus meds) to be sure you don't go over the 4000mg.
You are much better off taking just regular old Extra Strength Tylenol (2x 500mg tablets) for a regular dose, not to exceed 4000mg in any 24 hour period. You must also count the acetaminophen in any other meds you take (pain medications or cold and sinus meds) to be sure you don't go over the 4000mg.