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Acetaminophen (Tylenol, paracetamol) safety

Discussion in 'Pain Management' started by Josephine, Dec 11, 2010.

  1. Josephine

    Josephine FORUM ADMIN, NURSE DIRECTOR Administrator
    Thread Starter

    Member Since:
    Jun 8, 2007
    The North
    United Kingdom United Kingdom
    November 29, 2010 Medscape article (subscription viewing only[free])

    Hepatoxicity after therapeutic dosing of acetaminophen in children is rarely reported in studies, according to the results of a review reported online November 22 in Pediatrics.

    "Use of the drug has recently come under increased scrutiny by the Food and Drug Administration because of the increased recognition of the contribution of acetaminophen to acute liver injury globally," Dr. Laura James, section chief of clinical pharmacology and toxicology at Arkansas Children's Hospital and professor of pediatrics at University of Arkansas for Medical Sciences, told Medscape Medical News when asked for independent comment. "While most experts view acetaminophen to be safe when used as directed, there have been rare reports of toxicity occurring with recommended dosing of the drug. Individual susceptibilities in drug response and toxicity may occur with the use of any drug, including acetaminophen."

    Acetaminophen is a drug with a narrow safety index and thus careful dosing of the drug is a necessity for safe use.

    ~ maximum dosage per 24hrs should not exceed 4,000mgs
    ~ to be taken at not less than 4hrly intervals ~ thus 1,000mgs 4 times per 24hr period

    When taking acetaminophen (Tylenol) for pain relief, be sure to count all of the prescription and over-the-counter medications you take that has it as an ingredient. Here is a link that provides a fairly comprehensive list of medications you might not be aware of that contain acetaminophen:
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